Publications

1. Clinical Pharmacokinetics and Preclinical Pharmacodynamics of (+)-Epicatechin on Cardiometabolic Endpoints Moreno-Ulloaa A, Najera-Garciac N, Hernandezc M, Ramirez-Sanchez I, Taub P, Sue Y, Ceballos G, Dugar S, Schreiner G, Ciaraldia T, Henry R and Villarreal F.

2. Pharmacokinetic, partial pharmacodynamic and initial safety analysis of (−)-Epicatechin in healthy volunteers Barnett C, Moreno A, Shiva S, Ramirez-Sanchez I, Taub P, Su Y, Ceballos G, Dugar S, Schreiner G, Villarreal F: Food Funct. 2015 Mar 11; 6(3): 824–833. doi: 10.1039/c4fo00596a

3. Co-administration of the flavanol (-)-epicatechin with doxycycline synergistically reduces infarct size in a model of ischemia reperfusion injury by inhibition of mitochondrial swelling Ortiz-Vilchis P., Go Yamazaki K., Rubio-Gayosso I., Ramirez-Sanchez I., Calzada C., Romero-Perez D., Ortiz A., Meaney E., Taub P., Villarreal F., Ceballos G.; European Journal of Pharmacology Volume 744, 5 December 2014, Pages 76–82

4. Recovery of indicators of mitochondrial biogenesis, oxidative stress and aging with (-)-epicatechin in senile mice. Moreno-Ulloa A, Nogueira L, Rodriguez A, Barboza J, Hogan M, Ceballos G, Villarreal F, Ramírez-Sánchez I: J Gerontol A Biol Sci Med Sci. pii: glu131, 2014

5. The Science of Cocoa Flavanols: Bioavailability, Emerging Evidence and Proposed Mechanisms. Ding E, Dixon R, Pasinetti G, Villarreal F, Blumberg J: Adv Nutr September 2014 Adv Nutr vol. 5: 547-549, 2014.

6. (–)-Epicatechin improves mitochondrial-related protein levels and ameliorates oxidative stress in dystrophic δ-sarcoglycan null mouse striated muscle Ramírez-Sánchez I, Santos S, Gonzalez-Basurto S, Canto P, Mendoza-Lorenzo P, Palma-Flores C, Ceballos-Reyes G, Villarreal F, Zentella-Dehesa A and Coral-Vazquez R: FEBS Journal. DOI: 10.1111/febs.13098, 2014.

7. Intravenous (-)-epicatechin reduces ischemia-reperfusion injury by protecting myocardial bioenergetics. Yamazaki K, Ortiz-Vilchis P, Andreyev A, Petrosyan S, De La Fuente C, Ceballos G, Villarreal F, Murphy A: Int J Cardiol, 2014: August 1, 2014, Volume 175, Issue 2, Pages 297–306.

8. Cell membrane mediated effects of (-)-epicatechin on upstream cell signaling: Evidence for a cell surface receptor. Moreno, A, Ceballos G, Villarreal, F, Ramírez-Sánchez I: 2014 Jun 15;24(12):2749-52. doi: 10.1016/j.bmcl.2014.04.038. Epub 2014 Apr 19.

9. Effects of (-)-epicatechin on metabolism in rat models of obesity and metabolic syndrome. Gutierrez-Salmean G, Ramírez-Sánchez I, Villarreal, F, Ceballos G: Eur J Pharm, 728:24-30, 2014.

10. Acute effects of an oral supplement of (-)-epicatechin on postprandial fat and carbohydrate metabolism in normal and overweight subjects. Gutiérrez-Salmeán G, Ortiz-Vilchis P, Vacaseydel CM, Rubio-Gayosso I, Meaney E, Villarreal F, Ramírez-Sánchez I, Ceballos G. Food Funct. 2014 Mar;5(3):521-7. doi: 10.1039/c3fo60416k.

11. Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation. Gutierrez-Salmean G, Ciaraldi T, Nogueira L, Taub P, Hogan M, Henry R, Meany E, Villarreal, F Ceballos G, Ramirez-Sanchez I: J Nut Biochem, 25:91-94, 2014.

12. (-)-Epicatechin rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and type 2 diabetes patients. Ramirez-Sanchez I, Taub P, Nogueira L, Ciaraldi T, Hogan M, Maisel A, Henry R, Ceballos G, Villarreal, F: Int J Cardiol, 168:3982-3990, 2013.

13. Effects of (-)-epicatechin and derivatives on nitric oxide mediated induction of mitochondrial proteins. Moreno-Ulloa A, Cid A, Rubio-Gayosso, Ceballos G, Villarreal F, Ramirez-Sanchez I. Bioorganic and Med Chem Letters, 23:4441-6, 2013.

14. Perturbations in skeletal muscle sarcomere structure of heart failure and type 2 diabetes patients: Restorative effects of (-)-epicatechin-rich cocoa. Taub P, Ramirez-Sanchez I, Ciaraldi T, Gonzalez-Basurto S, Coral-Vazquez R, Perkins G, Hogan M, Maisel A, Henry R, Ceballos G, Villarreal, F: Clin Sci, 125:383-89, 2013.

15. Epicatechin limits renal injury by mitochondrial protection in cisplatin nephropathy. Tanabe K, Tamura Y, Lanaspa M, Miyazaki M, Suzuki N, Sato W, Maeshima Y, Villarreal F, Schreiner G, Johnson J, Nakagawa T: Am J Phys, 303:F1264-74, 2012.

16. (-)-Epicatechin induced calcium independent eNOS activation: Roles of HSP90 and AKT. Ramírez-Sánchez I, Maya L, Ceballos G, Villarreal, F: Moll Cell Biochem, 370:141-150, 2012.

17. Stimulatory effects of the flavanol (-)-epicatechin on cardiac angiogenesis: Additive effects with exercise. Ramirez-Sanchez, Nogueira L, Moreno A, Murphy A, Taub P, Perkins G, Ceballos GM, Hogan M, Malek M, Villarreal F. J Cardiovasc Pharmacol. 2012 Nov;60(5):429-38. doi: 10.1097/FJC.0b013e318269ae0d.

18. Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: Effects of epicatechin rich cocoa. Taub P, Ramirez-Sanchez I, Ciaraldi T, Perkins G, Murphy A, Naviaux R, Hogan M, Maisel A, Henry R, Ceballos G, Villarreal F: Clin Trans Sci, 5:43-47, 2012.

19. The beneficial vascular effects of cacao flavanols: having your cake and eating it too. Ceballos G, Villarreal F: J App Phys, 111:1544, 2011.

20. Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. Nogueira L, Ramirez-Sanchez I, Perkins G, Murphy A, Taub P, Ceballos G, Villarreal F, Hogan M, Malek M: (-)-J Phys, 589:4615-4631, 2011.

21. (-)-Epicatechin induces calcium and translocation independent eNOS activation in arterial endothelial cells. Ramírez-Sánchez, I, Maya, L, Ceballos, G, Villarreal, F: Am J Phys, 300:C880-887, 2011.

22. Fluorescent detection of (-)-epicatechin in microsamples from cacao seeds and cocoa products: Comparison with Folin-Ciocalteu method. Ramírez-Sánchez I, Maya L, Ceballos G, Villarreal, F: J Food Comp Anal, 23:790-793, 2010.

23. Epicatechin activation of endothelial cell eNOS, NO and related signaling pathways. Ramírez-Sánchez I, Maya L, Ceballos G, Villarreal, F: 55:1398-1405, 2010.

24. Fluorescent detection of (-)-epicatechin in microsamples from cacao seeds and cocoa products: Comparison with Folin-Ciocalteu method. Ramírez-Sánchez I, Maya L, Ceballos G, Villarreal, F: J Food Comp Anal, 23:790-793, 2010.

25. Cardioprotective effects of (-)-epicatechin in a model of permanent coronary occlusion-induced myocardial infarction. Yamazaki, K, Rajendran, P, Barraza, M, Rivas, M, Zambon, A, Ceballos, G, Villarreal, F: J Am Coll Cardiol, 55:2869-2876, 2010.

26. Short and long term effects of (-)-epicatechin on myocardial ischemia-reperfusion injury. Go, K, Romero-Perez, D, Barraza, M, Cruz, M, Cortez-Gomez, B, Rivas, M, Ceballos, G, Villarreal, F: Am J Phys, 295:H761-767, 2008.